The Senescence, Aging, Infection and Immunity (SAIL) laboratory studies immune responses in chronic and persistent viral infections (HIV, CMV, HCV); the role of chronic viral infection in chronologic and immunologic aging; interactions between innate and adaptive immunity in chronic viral infection and the modulation of the immune response to generate therapeutic and prophylactic vaccines in persistent viral infections. Clinically Dr. Barrett is also interested in treating viral infections in underserved and incarcerated populations.
Read MoreDr. Michael Bezuhly is an Assistant Professor in Departments of Surgery and Microbiology and Immunology at Dalhousie University. Originally from Toronto, he speaks English, Russian and French. He completed his undergraduate degree at McGill University in 1999 and his medical degree at the University of Toronto in 2003. During his residency training in plastic surgery and in the Clinician-Investigator Program he obtained graduate degrees in Anatomy and Neurobiology from Dalhousie University and Epidemiology from Harvard University. After completing residency training at Dalhousie University in 2010, Dr. Bezuhly received additional subspecialty training in pediatric plastic surgery at the Hospital for Sick Children, and in pediatric craniofacial surgery at the Hopital Necker-Enfants Malades in Paris, France.
Read MoreWe investigate how human natural killer cell immunogenetics program immune responsiveness to cancer and infectious diseases. We use bioinformatics, humanized in vivo models, cell-signal analysis, and highly-parametric flow cytometry to understand how genetic variation creates diversity in human immune potentials. Our interdisciplinary and collaborative work aims to translate research findings into precision therapies.
Read MoreDrs. Beata Derfalvi and Thomas Issekutz provide clinical immunology care to children throughout the Maritimes through an inpatient attending and consultation service and a weekly immunology outpatient clinic. The services focus on patients with chronic immunological conditions involving primary and secondary immunodeficiencies and autoimmune processes.
Read MoreOur research relies primarily on the use of Drosophila, a genetically amenable model system, to elucidate the previously unexplored role of peroxisomes as signaling platforms in the innate immune response. We demonstrated the peroxisome direct involvement in immune defense, with evidence of peroxisome requirements in phagocytic pathogen clearance and innate immune signaling in immune responsive tissue in flies and mammals. Peroxisomes are essential metabolic organelles present in every eukaryotic cell.
Read MoreDr. Gujar’s research program focuses on molecular and immunological aspects of human health, with special focus on cancer immunotherapies. His multi-disciplinary interests include Oncolytic viruses, Immunology and immunotherapies, Epitope discovery, Cellular biology and metabolism, Applied immunomics and Proteo-immuno-metabolomics.
Read MoreDr. Hanly’s major research foci are pathogenic mechanisms and clinical outcomes in systemic lupus erythematosus, with emphasis on how lupus affects the brain and other parts of the nervous system. Dr. Hanly also collaborates on studies of pathogenic mechanisms in patients with rheumatoid arthritis. He belongs to several national and international research networks involving clinical studies of systemic lupus erythematosus.
Read MoreDr. Thomas Issekutz provides clinical immunology care to children throughout the Maritimes through an inpatient attending and consultation service and a weekly immunology outpatient clinic. The services focus on patients with chronic immunological conditions involving primary and secondary immunodeficiencies and autoimmune processes.
Read MoreDr. Brent Johnston’s research focuses on immune cell development, homing, and activation. We are currently studying the regulation of autoimmunity and anti-tumour immune responses by natural killer T (NKT) cells, a subset of leukocytes that bridge the innate and adaptive immune systems.
Read MoreDr Légaré is the Head of Cardiac Surgery at the New Brunswick Heart Centre and Professor of Surgery at Dalhousie University Medicine New Brunswick located in Saint John New Brunswick.
Read MoreProfessor Lehmann’s research interests include the immune consequences of local and systemic inflammation (e.g., sepsis, stroke), intravital imaging of the microcirculation in animal models and clinical studies, and the development of new pharmacological approaches for inflammation and infection.
Read MoreDr. Makrigiannis’ research focus is the innate immune system, and in particular Natural Killer (NK) cell recognition of virally-infected or cancerous cells via the polymorphic Ly49 family of class I MHC receptors and the related NKR-P1 receptor family, in order to understand the contribution of NK cell receptors to diseases for translation into clinical therapies.
Read MoreDr. Marshall has a long term interest in the biology and function of mast cells in host defence and disease. This includes study of mast cells in models of viral infection, cancer and allergic disease such as asthma and food allergy. Her work often involves multidisciplinary teams of scientists and multiple research trainees.
Read MoreUsing animal models of rheumatoid arthritis, osteoarthritis and joint injury, Dr. McDougall's laboratory employs an integrative approach to examine the role of nerves in controlling joint inflammation and pain.
Read MoreDr. Sharon Oldford is an immunologist who works with Dr. Barrett to coordinate SAIL’s basic science research projects. Her current research interests include investigating the effects of chronic viral infection on immune phenotype and functional changes and experimental models of immunologic aging.
Read MoreProfessor Wang’s research interests include (1) understanding the role of regulatory T cells and IL-17/IL-17R axis in host responses to intracellular bacterial infection and cancer; (2) development of prophylactic and/or therapeutic vaccines against infection and cancer.
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