Chris Richardson
External Website:
Christopher Richardson Dalhousie University Profile
Research Interests
My research involves the molecular biology of measles, canine distemper, hepatitis C, and hepatitis B viruses. We are particularly interested in virus-host cell receptor interactions. Many of these receptors have been found to be highly up-regulated on cancer cells and can be targeted for therapy by recombinant oncolytic viruses.
Selected publications
Noyce R.S. and Richardson C.D. (2012) Nectin 4 is the Epithelial Cell Receptor for Measles Virus. Trends Microbiol. 20(9):429-39
Noyce R., Bondre D., Ha M., Sisson G., Tsao M., and Richardson C.D. (2011). The tumor cell marker PVRL4/Nectin 4 is an epithelial cell receptor for measles virus. PLoS Pathogens7(8): e1002240
Hsu, E.C., His, B., Hirota-Tsuchihara, M., Ruland, J., Iorio, C., Sarangi, F., Diao, J., Migliaccio, G., Tyrrell, D.L., Kneteman, N., and Richardson, C.D. (2003). Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers. Nature Biotechnology 21: 519-525
Dörig, R., Marcil, A., Chopra, A., and Richardson, C.D. (1993). The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295-305.