Craig McCormick
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Research Interests
Our research is focused on innate host antiviral defenses and the viral countermeasures that have evolved to subvert these defenses. We study two viruses, influenza virus and a cancer-causing herpesvirus known as KSHV.
Selected publications
Gaucherand L*, Porter BK*, Levene RE, Price EL, Schmaling SK, Rycroft CH, Kevorkian Y, McCormick C#, Khaperskyy DA#, Gaglia MM#. (2019) The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression. Cell Reports 27(3):776-792. * = co-first authors, # = co-corresponding authors
McCormick C, Khaperskyy DA. Translation inhibition and stress granules in the control of the antiviral immune response. Nat. Rev. Immunol., 2017 Jun 26. Doi: 10.1038/nri.2017.63. [Epub ahead of print] Review. PMID: 28669985
Khapersky DA, Schmaling S, Larkins-Ford J, McCormick C*, Gaglia MM* (2016) Selective degradation of host RNA polymerase II transcripts by influenza A virus PA-X host shutoff protein. PLoS Pathogens 12(2):e1005427 (*co-corresponding authors)
Corcoran JA, Johnston BP, McCormick C. (2015) Viral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilization. PLoS Pathog 11(1): e1004597.
Khaperskyy DA, Emara MM, Johnston BP, Anderson P, Hatchette TF, McCormick C. (2014) Influenza A virus blocks antiviral stress-induced translation arrest. PLoS Pathog. 10(7): e1004217.
Leidal AM, Cyr DP, Hill RJ, Lee PWK, McCormick C. (2012) Subversion of autophagy by Kaposi’s sarcoma-associated herpesvirus impairs oncogene-induced senescence. Cell Host & Microbe. 11(2):167-80.
Khaperskyy DA, Hatchette TF, McCormick C. (2012) Influenza A virus inhibits cytoplasmic stress granule formation. FASEB J. 26(4):1629-39.