Zhenyu Cheng
External Website:
Zhenyu Cheng Dalhousie University Profile
Research Interests
Dr. Cheng utilizes systems biology approaches to study the pathogenesis of infectious diseases. His research is relevant to multiple I3V research priorities including antimicrobial resistance, existing and emerging microbial threats, improved diagnostics directly related to infection and immunity, and inflammation. His goal is to identify signalling components in host immunity and bacterial pathogenesis pathways that can be exploited to treat pathogenic infections and enhance host immunity.
Pseudomonas aeruginosa infection and chronic inflammation in Cystic Fibrosis is a major translational research focus for Dr. Cheng.
Selected publications
Daboor SM, Rohde JR, Cheng Z (2020) Disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate lyase enhances pathogen eradication by antibiotics. Journal of Cystic Fibrosis. May 30:S1569-1993(20)30119-3.
Omar T, Ziltener P, Chamberlain E, Cheng Z, Johnston B (2020) Mice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines. Infection and Immunity 88(6):e00171-20.